CovidChloroV1, Main, Exploration, bibRecord, 000519

Efficacy of chloroquine or hydroxychloroquine in COVID-19 patients: a systematic review and meta-analysis.

Identifieur interne : 000519 ( Main/Exploration ); précédent : 000518; suivant : 000520

Efficacy of chloroquine or hydroxychloroquine in COVID-19 patients: a systematic review and meta-analysis.

Auteurs : Zakariya Kashour [Canada] ; Muhammad Riaz [Pakistan] ; Musa A. Garbati [Nigeria] ; Oweida Aldosary [Arabie saoudite] ; Haytham Tlayjeh [Arabie saoudite] ; Dana Gerberi [États-Unis] ; M Hassan Murad [États-Unis] ; M Rizwan Sohail [États-Unis] ; Tarek Kashour [Arabie saoudite] ; Imad M. Tleyjeh [Arabie saoudite, États-Unis]

Source :

The Journal of antimicrobial chemotherapy [ 1460-2091 ] ; 2021.

RBID : pubmed:33031488

Descripteurs français

KwdFr :
- Antiviraux (usage thérapeutique), Azithromycine (usage thérapeutique), Chloroquine (effets indésirables), Chloroquine (usage thérapeutique), Essais contrôlés randomisés comme sujet (MeSH), Hospitalisation (statistiques et données numériques), Humains (MeSH), Hydroxychloroquine (effets indésirables), Hydroxychloroquine (usage thérapeutique), Résultat thérapeutique (MeSH).
MESH :
- effets indésirables : Chloroquine, Hydroxychloroquine.
- statistiques et données numériques : Hospitalisation.
- usage thérapeutique : Antiviraux, Azithromycine, Chloroquine, Hydroxychloroquine.
- Essais contrôlés randomisés comme sujet, Humains, Résultat thérapeutique.

English descriptors

KwdEn :
- Antiviral Agents (therapeutic use), Azithromycin (therapeutic use), COVID-19 (drug therapy), COVID-19 (mortality), Chloroquine (adverse effects), Chloroquine (therapeutic use), Hospitalization (statistics & numerical data), Humans (MeSH), Hydroxychloroquine (adverse effects), Hydroxychloroquine (therapeutic use), Randomized Controlled Trials as Topic (MeSH), Treatment Outcome (MeSH).
MESH :
- chemical , adverse effects : Chloroquine, Hydroxychloroquine.
- chemical , therapeutic use : Antiviral Agents, Azithromycin, Chloroquine, Hydroxychloroquine.
- drug therapy : COVID-19.
- mortality : COVID-19.
- statistics & numerical data : Hospitalization.
- Humans, Randomized Controlled Trials as Topic, Treatment Outcome.

Abstract

OBJECTIVES

Clinical studies of chloroquine (CQ) and hydroxychloroquine (HCQ) in COVID-19 disease reported conflicting results. We sought to systematically evaluate the effect of CQ and HCQ with or without azithromycin on outcomes of COVID-19 patients.

METHODS

We searched multiple databases, preprints and grey literature up to 17 July 2020. We pooled only adjusted-effect estimates of mortality using a random-effect model. We summarized the effect of CQ or HCQ on viral clearance, ICU admission/mechanical ventilation and hospitalization.

RESULTS

Seven randomized clinical trials (RCTs) and 14 cohort studies were included (20 979 patients). Thirteen studies (1 RCT and 12 cohort studies) with 15 938 hospitalized patients examined the effect of HCQ on short-term mortality. The pooled adjusted OR was 1.05 (95% CI 0.96-1.15, I2 = 0%). Six cohort studies examined the effect of the HCQ+azithromycin combination with a pooled adjusted OR of 1.32 (95% CI 1.00-1.75, I2 = 68.1%). Two cohort studies and four RCTs found no effect of HCQ on viral clearance. One small RCT demonstrated improved viral clearance with CQ and HCQ. Three cohort studies found that HCQ had no significant effect on mechanical ventilation/ICU admission. Two RCTs found no effect for HCQ on hospitalization risk in outpatients with COVID-19.

CONCLUSIONS

Moderate certainty evidence suggests that HCQ, with or without azithromycin, lacks efficacy in reducing short-term mortality in patients hospitalized with COVID-19 or risk of hospitalization in outpatients with COVID-19.

DOI: 10.1093/jac/dkaa403
PubMed: 33031488
PubMed Central: PMC7665543

Affiliations:

Arabie saoudite, Canada, Nigeria, Pakistan, États-Unis
Minnesota

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Le document en format XML

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<author><name sortKey="Sohail, M Rizwan" sort="Sohail, M Rizwan" uniqKey="Sohail M" first="M Rizwan" last="Sohail">M Rizwan Sohail</name>
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<wicri:regionArea>Department of Cardiovascular Diseases, Mayo Clinic College of Medicine and Science, Rochester, MN</wicri:regionArea>
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<author><name sortKey="Kashour, Tarek" sort="Kashour, Tarek" uniqKey="Kashour T" first="Tarek" last="Kashour">Tarek Kashour</name>
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<author><name sortKey="Tleyjeh, Imad M" sort="Tleyjeh, Imad M" uniqKey="Tleyjeh I" first="Imad M" last="Tleyjeh">Imad M. Tleyjeh</name>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Antiviral Agents (therapeutic use)</term>
<term>Azithromycin (therapeutic use)</term>
<term>COVID-19 (drug therapy)</term>
<term>COVID-19 (mortality)</term>
<term>Chloroquine (adverse effects)</term>
<term>Chloroquine (therapeutic use)</term>
<term>Hospitalization (statistics & numerical data)</term>
<term>Humans (MeSH)</term>
<term>Hydroxychloroquine (adverse effects)</term>
<term>Hydroxychloroquine (therapeutic use)</term>
<term>Randomized Controlled Trials as Topic (MeSH)</term>
<term>Treatment Outcome (MeSH)</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Antiviraux (usage thérapeutique)</term>
<term>Azithromycine (usage thérapeutique)</term>
<term>Chloroquine (effets indésirables)</term>
<term>Chloroquine (usage thérapeutique)</term>
<term>Essais contrôlés randomisés comme sujet (MeSH)</term>
<term>Hospitalisation (statistiques et données numériques)</term>
<term>Humains (MeSH)</term>
<term>Hydroxychloroquine (effets indésirables)</term>
<term>Hydroxychloroquine (usage thérapeutique)</term>
<term>Résultat thérapeutique (MeSH)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="adverse effects" xml:lang="en"><term>Chloroquine</term>
<term>Hydroxychloroquine</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Antiviral Agents</term>
<term>Azithromycin</term>
<term>Chloroquine</term>
<term>Hydroxychloroquine</term>
</keywords>
<keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>COVID-19</term>
</keywords>
<keywords scheme="MESH" qualifier="effets indésirables" xml:lang="fr"><term>Chloroquine</term>
<term>Hydroxychloroquine</term>
</keywords>
<keywords scheme="MESH" qualifier="mortality" xml:lang="en"><term>COVID-19</term>
</keywords>
<keywords scheme="MESH" qualifier="statistics & numerical data" xml:lang="en"><term>Hospitalization</term>
</keywords>
<keywords scheme="MESH" qualifier="statistiques et données numériques" xml:lang="fr"><term>Hospitalisation</term>
</keywords>
<keywords scheme="MESH" qualifier="usage thérapeutique" xml:lang="fr"><term>Antiviraux</term>
<term>Azithromycine</term>
<term>Chloroquine</term>
<term>Hydroxychloroquine</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Humans</term>
<term>Randomized Controlled Trials as Topic</term>
<term>Treatment Outcome</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Essais contrôlés randomisés comme sujet</term>
<term>Humains</term>
<term>Résultat thérapeutique</term>
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<front><div type="abstract" xml:lang="en"><p><b>OBJECTIVES</b>
</p>
<p>Clinical studies of chloroquine (CQ) and hydroxychloroquine (HCQ) in COVID-19 disease reported conflicting results. We sought to systematically evaluate the effect of CQ and HCQ with or without azithromycin on outcomes of COVID-19 patients.</p>
</div>
<div type="abstract" xml:lang="en"><p><b>METHODS</b>
</p>
<p>We searched multiple databases, preprints and grey literature up to 17 July 2020. We pooled only adjusted-effect estimates of mortality using a random-effect model. We summarized the effect of CQ or HCQ on viral clearance, ICU admission/mechanical ventilation and hospitalization.</p>
</div>
<div type="abstract" xml:lang="en"><p><b>RESULTS</b>
</p>
<p>Seven randomized clinical trials (RCTs) and 14 cohort studies were included (20 979 patients). Thirteen studies (1 RCT and 12 cohort studies) with 15 938 hospitalized patients examined the effect of HCQ on short-term mortality. The pooled adjusted OR was 1.05 (95% CI 0.96-1.15, I2 = 0%). Six cohort studies examined the effect of the HCQ+azithromycin combination with a pooled adjusted OR of 1.32 (95% CI 1.00-1.75, I2 = 68.1%). Two cohort studies and four RCTs found no effect of HCQ on viral clearance. One small RCT demonstrated improved viral clearance with CQ and HCQ. Three cohort studies found that HCQ had no significant effect on mechanical ventilation/ICU admission. Two RCTs found no effect for HCQ on hospitalization risk in outpatients with COVID-19.</p>
</div>
<div type="abstract" xml:lang="en"><p><b>CONCLUSIONS</b>
</p>
<p>Moderate certainty evidence suggests that HCQ, with or without azithromycin, lacks efficacy in reducing short-term mortality in patients hospitalized with COVID-19 or risk of hospitalization in outpatients with COVID-19.</p>
</div>
</front>
</TEI>
<pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">33031488</PMID>
<DateCompleted><Year>2020</Year>
<Month>12</Month>
<Day>29</Day>
</DateCompleted>
<DateRevised><Year>2021</Year>
<Month>01</Month>
<Day>10</Day>
</DateRevised>
<Article PubModel="Print"><Journal><ISSN IssnType="Electronic">1460-2091</ISSN>
<JournalIssue CitedMedium="Internet"><Volume>76</Volume>
<Issue>1</Issue>
<PubDate><Year>2021</Year>
<Month>01</Month>
<Day>01</Day>
</PubDate>
</JournalIssue>
<Title>The Journal of antimicrobial chemotherapy</Title>
<ISOAbbreviation>J Antimicrob Chemother</ISOAbbreviation>
</Journal>
<ArticleTitle>Efficacy of chloroquine or hydroxychloroquine in COVID-19 patients: a systematic review and meta-analysis.</ArticleTitle>
<Pagination><MedlinePgn>30-42</MedlinePgn>
</Pagination>
<ELocationID EIdType="doi" ValidYN="Y">10.1093/jac/dkaa403</ELocationID>
<Abstract><AbstractText Label="OBJECTIVES">Clinical studies of chloroquine (CQ) and hydroxychloroquine (HCQ) in COVID-19 disease reported conflicting results. We sought to systematically evaluate the effect of CQ and HCQ with or without azithromycin on outcomes of COVID-19 patients.</AbstractText>
<AbstractText Label="METHODS">We searched multiple databases, preprints and grey literature up to 17 July 2020. We pooled only adjusted-effect estimates of mortality using a random-effect model. We summarized the effect of CQ or HCQ on viral clearance, ICU admission/mechanical ventilation and hospitalization.</AbstractText>
<AbstractText Label="RESULTS">Seven randomized clinical trials (RCTs) and 14 cohort studies were included (20 979 patients). Thirteen studies (1 RCT and 12 cohort studies) with 15 938 hospitalized patients examined the effect of HCQ on short-term mortality. The pooled adjusted OR was 1.05 (95% CI 0.96-1.15, I2 = 0%). Six cohort studies examined the effect of the HCQ+azithromycin combination with a pooled adjusted OR of 1.32 (95% CI 1.00-1.75, I2 = 68.1%). Two cohort studies and four RCTs found no effect of HCQ on viral clearance. One small RCT demonstrated improved viral clearance with CQ and HCQ. Three cohort studies found that HCQ had no significant effect on mechanical ventilation/ICU admission. Two RCTs found no effect for HCQ on hospitalization risk in outpatients with COVID-19.</AbstractText>
<AbstractText Label="CONCLUSIONS">Moderate certainty evidence suggests that HCQ, with or without azithromycin, lacks efficacy in reducing short-term mortality in patients hospitalized with COVID-19 or risk of hospitalization in outpatients with COVID-19.</AbstractText>
<CopyrightInformation>© The Author(s) 2020. Published by Oxford University Press on behalf of the British Society for Antimicrobial Chemotherapy. All rights reserved. For permissions, please email: journals.permissions@oup.com.</CopyrightInformation>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Kashour</LastName>
<ForeName>Zakariya</ForeName>
<Initials>Z</Initials>
<AffiliationInfo><Affiliation>Department of Medicine, University of Alberta, Edmonton, AB, Canada.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Riaz</LastName>
<ForeName>Muhammad</ForeName>
<Initials>M</Initials>
<AffiliationInfo><Affiliation>Department of Statistics, Quaid-i-Azam University Islamabad, Islamabad, Pakistan.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Garbati</LastName>
<ForeName>Musa A</ForeName>
<Initials>MA</Initials>
<AffiliationInfo><Affiliation>Infectious Diseases Unit, Department of Medicine, University of Maiduguri, Maiduguri, Nigeria.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>AlDosary</LastName>
<ForeName>Oweida</ForeName>
<Initials>O</Initials>
<AffiliationInfo><Affiliation>Infectious Diseases Section, Department of Medical Specialties, King Fahad Medical City, Riyadh, Saudi Arabia.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Tlayjeh</LastName>
<ForeName>Haytham</ForeName>
<Initials>H</Initials>
<AffiliationInfo><Affiliation>Department of Intensive Care, King Abdulaziz Medical City, King Saud bin Abdulaziz for Health Sciences and King Abdullah International Medical Research Center, Riyadh, Saudi Arabia.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Gerberi</LastName>
<ForeName>Dana</ForeName>
<Initials>D</Initials>
<AffiliationInfo><Affiliation>Mayo Clinic Libraries, Mayo Clinic, Rochester, MN, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Murad</LastName>
<ForeName>M Hassan</ForeName>
<Initials>MH</Initials>
<AffiliationInfo><Affiliation>Division of Health Care Policy & Research, Department of Health Sciences Research, Mayo Clinic College of Medicine and Science, Rochester, MN, USA.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Division of Preventive, Occupational and Aerospace Medicine, Department of Internal Medicine, Mayo Clinic College of Medicine and Science, Rochester, MN, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Sohail</LastName>
<ForeName>M Rizwan</ForeName>
<Initials>MR</Initials>
<AffiliationInfo><Affiliation>Division of Infectious Diseases, Mayo Clinic College of Medicine and Science, Rochester, MN, USA.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Department of Cardiovascular Diseases, Mayo Clinic College of Medicine and Science, Rochester, MN, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Kashour</LastName>
<ForeName>Tarek</ForeName>
<Initials>T</Initials>
<AffiliationInfo><Affiliation>Department of Cardiac Sciences, King Fahad Cardiac Center, King Saud University Medical City, Riyadh, Saudi Arabia.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Tleyjeh</LastName>
<ForeName>Imad M</ForeName>
<Initials>IM</Initials>
<AffiliationInfo><Affiliation>Infectious Diseases Section, Department of Medical Specialties, King Fahad Medical City, Riyadh, Saudi Arabia.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Division of Infectious Diseases, Mayo Clinic College of Medicine and Science, Rochester, MN, USA.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Division of Epidemiology, Mayo Clinic College of Medicine and Science, Rochester, MN, USA.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>College of Medicine, Alfaisal University, Riyadh, Saudi Arabia.</Affiliation>
</AffiliationInfo>
</Author>
</AuthorList>
<Language>eng</Language>
<PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType>
<PublicationType UI="D017418">Meta-Analysis</PublicationType>
<PublicationType UI="D000078182">Systematic Review</PublicationType>
</PublicationTypeList>
</Article>
<MedlineJournalInfo><Country>England</Country>
<MedlineTA>J Antimicrob Chemother</MedlineTA>
<NlmUniqueID>7513617</NlmUniqueID>
<ISSNLinking>0305-7453</ISSNLinking>
</MedlineJournalInfo>
<ChemicalList><Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D000998">Antiviral Agents</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>4QWG6N8QKH</RegistryNumber>
<NameOfSubstance UI="D006886">Hydroxychloroquine</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>83905-01-5</RegistryNumber>
<NameOfSubstance UI="D017963">Azithromycin</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>886U3H6UFF</RegistryNumber>
<NameOfSubstance UI="D002738">Chloroquine</NameOfSubstance>
</Chemical>
</ChemicalList>
<CitationSubset>IM</CitationSubset>
<MeshHeadingList><MeshHeading><DescriptorName UI="D000998" MajorTopicYN="N">Antiviral Agents</DescriptorName>
<QualifierName UI="Q000627" MajorTopicYN="Y">therapeutic use</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D017963" MajorTopicYN="N">Azithromycin</DescriptorName>
<QualifierName UI="Q000627" MajorTopicYN="N">therapeutic use</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D000086382" MajorTopicYN="N">COVID-19</DescriptorName>
<QualifierName UI="Q000188" MajorTopicYN="Y">drug therapy</QualifierName>
<QualifierName UI="Q000401" MajorTopicYN="N">mortality</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D002738" MajorTopicYN="N">Chloroquine</DescriptorName>
<QualifierName UI="Q000009" MajorTopicYN="N">adverse effects</QualifierName>
<QualifierName UI="Q000627" MajorTopicYN="Y">therapeutic use</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D006760" MajorTopicYN="N">Hospitalization</DescriptorName>
<QualifierName UI="Q000706" MajorTopicYN="N">statistics & numerical data</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D006886" MajorTopicYN="N">Hydroxychloroquine</DescriptorName>
<QualifierName UI="Q000009" MajorTopicYN="N">adverse effects</QualifierName>
<QualifierName UI="Q000627" MajorTopicYN="Y">therapeutic use</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D016032" MajorTopicYN="N">Randomized Controlled Trials as Topic</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D016896" MajorTopicYN="N">Treatment Outcome</DescriptorName>
</MeshHeading>
</MeshHeadingList>
</MedlineCitation>
<PubmedData><History><PubMedPubDate PubStatus="received"><Year>2020</Year>
<Month>07</Month>
<Day>22</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="accepted"><Year>2020</Year>
<Month>08</Month>
<Day>28</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="pubmed"><Year>2020</Year>
<Month>10</Month>
<Day>9</Day>
<Hour>6</Hour>
<Minute>0</Minute>
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<PubMedPubDate PubStatus="medline"><Year>2020</Year>
<Month>12</Month>
<Day>30</Day>
<Hour>6</Hour>
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<ArticleId IdType="doi">10.1093/jac/dkaa403</ArticleId>
<ArticleId IdType="pmc">PMC7665543</ArticleId>
</ArticleIdList>
<ReferenceList><Reference><Citation>N Engl J Med. 2012 May 17;366(20):1881-90</Citation>
<ArticleIdList><ArticleId IdType="pubmed">22591294</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Influenza Other Respir Viruses. 2007 Sep-Nov;1(5-6):189-92</Citation>
<ArticleIdList><ArticleId IdType="pubmed">19453426</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>BMJ. 2009 Jul 21;339:b2700</Citation>
<ArticleIdList><ArticleId IdType="pubmed">19622552</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>BMJ. 2020 May 14;369:m1844</Citation>
<ArticleIdList><ArticleId IdType="pubmed">32409486</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Vector Borne Zoonotic Dis. 2008 Dec;8(6):837-9</Citation>
<ArticleIdList><ArticleId IdType="pubmed">18620511</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>JAMA. 2020 Jun 23;323(24):2493-2502</Citation>
<ArticleIdList><ArticleId IdType="pubmed">32392282</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Rheumatol. 2020 May 11;:</Citation>
<ArticleIdList><ArticleId IdType="pubmed">32393664</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Clin Epidemiol. 2017 Apr;84:121-129</Citation>
<ArticleIdList><ArticleId IdType="pubmed">28188897</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Kidney Int. 2020 Jul;98(1):20-26</Citation>
<ArticleIdList><ArticleId IdType="pubmed">32437768</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Ann Intern Med. 2020 Aug 18;173(4):287-296</Citation>
<ArticleIdList><ArticleId IdType="pubmed">32459529</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Zhejiang Da Xue Xue Bao Yi Xue Ban. 2020 May 25;49(2):215-219</Citation>
<ArticleIdList><ArticleId IdType="pubmed">32391667</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Am J Epidemiol. 2007 Sep 15;166(6):646-55</Citation>
<ArticleIdList><ArticleId IdType="pubmed">17615092</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Clin Epidemiol. 2010 Feb;63(2):130-5</Citation>
<ArticleIdList><ArticleId IdType="pubmed">20122499</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Cell Res. 2020 Mar;30(3):269-271</Citation>
<ArticleIdList><ArticleId IdType="pubmed">32020029</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Mayo Clin Proc Innov Qual Outcomes. 2020 Nov 2;:</Citation>
<ArticleIdList><ArticleId IdType="pubmed">33163895</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Clin Infect Dis. 2020 Nov 19;71(16):2227-2229</Citation>
<ArticleIdList><ArticleId IdType="pubmed">32255489</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Clin Infect Dis. 2020 Jul 28;71(15):732-739</Citation>
<ArticleIdList><ArticleId IdType="pubmed">32150618</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>BMJ. 2008 Apr 26;336(7650):924-6</Citation>
<ArticleIdList><ArticleId IdType="pubmed">18436948</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>JAMA. 2020 Jun 23;323(24):2524-2526</Citation>
<ArticleIdList><ArticleId IdType="pubmed">32463459</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Ann Intern Med. 2020 Oct 20;173(8):623-631</Citation>
<ArticleIdList><ArticleId IdType="pubmed">32673060</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>PLoS Negl Trop Dis. 2010 Aug 10;4(8):e785</Citation>
<ArticleIdList><ArticleId IdType="pubmed">20706626</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Int J Infect Dis. 2020 Aug;97:396-403</Citation>
<ArticleIdList><ArticleId IdType="pubmed">32623082</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>FASEB J. 2020 May;34(5):6027-6037</Citation>
<ArticleIdList><ArticleId IdType="pubmed">32350928</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Gen Virol. 2015 Dec;96(12):3484-3492</Citation>
<ArticleIdList><ArticleId IdType="pubmed">26459826</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Clin Infect Dis. 2020 Apr 27;:</Citation>
<ArticleIdList><ArticleId IdType="pubmed">32338708</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Biosci Trends. 2020 Mar 16;14(1):72-73</Citation>
<ArticleIdList><ArticleId IdType="pubmed">32074550</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Lancet. 2020 Jun 20;395(10241):1907-1918</Citation>
<ArticleIdList><ArticleId IdType="pubmed">32473681</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Travel Med Infect Dis. 2020 May - Jun;35:101735</Citation>
<ArticleIdList><ArticleId IdType="pubmed">32387694</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>PLoS One. 2013;8(4):e60579</Citation>
<ArticleIdList><ArticleId IdType="pubmed">23577127</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Cell Discov. 2020 Mar 18;6:16</Citation>
<ArticleIdList><ArticleId IdType="pubmed">32194981</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>JAMA Netw Open. 2020 Apr 24;3(4):e208857</Citation>
<ArticleIdList><ArticleId IdType="pubmed">32330277</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Gen Virol. 1969 Mar;4(2):203-14</Citation>
<ArticleIdList><ArticleId IdType="pubmed">4306296</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Clin Infect Dis. 2020 Jul 16;:</Citation>
<ArticleIdList><ArticleId IdType="pubmed">32674126</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>CMAJ. 2020 Jul 6;192(27):E734-E744</Citation>
<ArticleIdList><ArticleId IdType="pubmed">32493740</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Mayo Clin Proc. 2017 Mar;92(3):423-433</Citation>
<ArticleIdList><ArticleId IdType="pubmed">28259229</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Mol Cell Biol. 2020 May 18;12(4):322-325</Citation>
<ArticleIdList><ArticleId IdType="pubmed">32236562</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>PLoS One. 2020 Aug 13;15(8):e0237693</Citation>
<ArticleIdList><ArticleId IdType="pubmed">32790733</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Ann Intern Med. 2020 Jul 21;173(2):137-142</Citation>
<ArticleIdList><ArticleId IdType="pubmed">32422063</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Med (N Y). 2020 Dec 18;1(1):114-127.e3</Citation>
<ArticleIdList><ArticleId IdType="pubmed">32838355</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Gen Intern Med. 2020 Jun 30;:</Citation>
<ArticleIdList><ArticleId IdType="pubmed">32607928</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Lancet. 2020 May 22;:</Citation>
<ArticleIdList><ArticleId IdType="pubmed">32450107</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Virol J. 2005 Aug 22;2:69</Citation>
<ArticleIdList><ArticleId IdType="pubmed">16115318</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>BMJ. 2019 Aug 28;366:l4898</Citation>
<ArticleIdList><ArticleId IdType="pubmed">31462531</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Circ Arrhythm Electrophysiol. 2017 Apr;10(4):</Citation>
<ArticleIdList><ArticleId IdType="pubmed">28408648</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Med Virol. 2010 May;82(5):817-24</Citation>
<ArticleIdList><ArticleId IdType="pubmed">20336760</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Autoimmun Rev. 2020 Jul;19(7):102566</Citation>
<ArticleIdList><ArticleId IdType="pubmed">32380315</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Microbiol Immunol. 2014 Jun;58(6):318-26</Citation>
<ArticleIdList><ArticleId IdType="pubmed">24773578</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Lancet Infect Dis. 2011 Sep;11(9):677-83</Citation>
<ArticleIdList><ArticleId IdType="pubmed">21550310</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Nefrologia. 2020 May - Jun;40(3):272-278</Citation>
<ArticleIdList><ArticleId IdType="pubmed">32389518</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>N Engl J Med. 2020 Jun 18;382(25):2411-2418</Citation>
<ArticleIdList><ArticleId IdType="pubmed">32379955</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Antimicrob Agents Chemother. 2014 Aug;58(8):4875-84</Citation>
<ArticleIdList><ArticleId IdType="pubmed">24841269</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Clin Ther. 1995 Jul-Aug;17(4):622-36</Citation>
<ArticleIdList><ArticleId IdType="pubmed">8565026</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Biochem Biophys Res Commun. 2004 Oct 8;323(1):264-8</Citation>
<ArticleIdList><ArticleId IdType="pubmed">15351731</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>PLoS One. 2019 Mar 14;14(3):e0212614</Citation>
<ArticleIdList><ArticleId IdType="pubmed">30870459</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Clin Infect Dis. 2020 Jun 18;:</Citation>
<ArticleIdList><ArticleId IdType="pubmed">32556143</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Viruses. 2016 Nov 29;8(12):</Citation>
<ArticleIdList><ArticleId IdType="pubmed">27916837</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Viruses. 2018 May 17;10(5):</Citation>
<ArticleIdList><ArticleId IdType="pubmed">29772762</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Int J Antimicrob Agents. 2020 Jul;56(1):105949</Citation>
<ArticleIdList><ArticleId IdType="pubmed">32205204</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Clin Ther. 1996 Nov-Dec;18(6):1080-92</Citation>
<ArticleIdList><ArticleId IdType="pubmed">9001825</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>HIV Med. 2015 Nov;16(10):585-90</Citation>
<ArticleIdList><ArticleId IdType="pubmed">26238012</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
</PubmedData>
</pubmed>
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   |clé=     pubmed:33031488
   |texte=   Efficacy of chloroquine or hydroxychloroquine in COVID-19 patients: a systematic review and meta-analysis.
}}

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HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i   -Sk "pubmed:33031488" \
       | HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd   \
       | NlmPubMed2Wicri -a CovidChloroV1

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	Serveur d'exploration COVID et hydrochloroquine
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Serveur d'exploration COVID et hydrochloroquine

Efficacy of chloroquine or hydroxychloroquine in COVID-19 patients: a systematic review and meta-analysis.

Efficacy of chloroquine or hydroxychloroquine in COVID-19 patients: a systematic review and meta-analysis.

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